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Safety: The Number I Flagged in June In June I called TRIUMPH-1's 11.3% discontinuation rate at 12 mg "a number worth watching," and compared it to roughly 67% for tirzepatide 15 mg in SURMOUNT

Allergic reactions are rare but documented

Listen to your body and be aware of how you feel during and after physical activity

However, small-molecule 3 was quite lipophilic (logD 7.4 = 5.7), resulting in high metabolic intrinsic clearance in human liver microsomes (HLM) (CL int = 130 mL/min/kg, Table S4), which would likely lead to a short pharmacokinetic half-life (t 1/2 ) and the requirement for an unacceptably high daily dose in humans