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Participants were randomized to placebo or one of six retatrutide dose cohorts and treated for 48 weeks

By comparison, Zepbound (tirzepatide) has FDA approval specifically for weight loss, while Mounjaro (tirzepatide) is FDA-approved for type 2 diabetes management

However, people with kidney disease, liver disease, seizure disorders, thyroid conditions, cardiovascular disease, pregnancy, breastfeeding, cancer history or prescription medication use should speak with a healthcare professional before supplementing

Effect of short- and long-term protein consumption on appetite and appetite-regulating gastrointestinal hormones, a systematic review and meta-analysis of randomized controlled trials