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It reduces the transfer of melanin pigment to the skin cells and hence, works amazingly in skin lightening treatment

The use the peptide Ac-Nle-c c/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH in the manufacture of a medicament for intranasal administration for use in the treatment of erectile dysfunction in a male, wherein the peptide Ac-Nle-cyc/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH increases cGMP levels to an amount sufficient to produce an erection sufficient for sexual intercourse when the peptide Ac-Nle-cyc/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH is administered at a sub-therapeutic dose and administered subsequent to a sub-therapeutic dose of a PDE-5 inhibitor