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Many women with lipedema spend years doing everything they were told to do
While clinical evidence 52,53 has indicated a possible elevated risk, causality has not been established
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The overall molecular properties of orforglipron, molecular weight approximately 529 Da, moderate lipophilicity (cLogP approximately 3.5), and limited hydrogen bond donors and acceptors, place it within the "drug-like" chemical space defined by Lipinski's Rule of Five, although at the upper boundary
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