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Endoscopy (2009) 41:10829

A practical clinic-friendly approach: Avoid stacking a million actives in one routine anyway

(iv) patients received sorafenib as a first-line treatment between January 1, 2023, and January 1, 2025, and demonstrated a therapeutic response after a minimum of three months of treatment, confirmed by imaging changes on either CT or MRI and/or a decrease in serum -fetoprotein (AFP) levels compared to previous measurements [34],(v) patients received regorafenib as a second line treatment after showing unresponsive from the sorafenib after a minimum of three months of treatment, confirmed by no imaging changes on either CT or MRI and/or an increase in serum -fetoprotein (AFP) levels compared to prior clinical measurement [35]

But having some form of regular movement established before you begin helps in two ways