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Increased muscle loss A 2024 meta-analysis of GLP-1 medications found that ~25% of total weight loss results from lean mass rather than fat, likely due to insufficient protein intake and resistance training among participants in these studies 1

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Five clusters were identified, with 14.0% of females with higher HOMA-IR in C5, while only 7% of those with lower HOMA-IR were in this cluster (p 12 years before diagnosis of diabetes (DM), followed by a meta-analysis

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