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Romand S, Jostock T, Fornaro M, Schmidt J, Ritter A, Wilms B, Laux H (2016) Improving expression of recombinant human IGF-1 using IGF-1R knockout CHO cell lines
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These studies generally demonstrate favorable safety profiles, although their therapeutic efficacy is often limited by poor aqueous solubility, rapid metabolism, and low systemic bioavailability
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