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Theoretical concerns based on mechanism include phosphate dysregulation from chronic renal phosphate wasting, potential antibody formation against the peptide sequence with repeated dosing, and unknown reproductive or developmental effects
If there is not enough evidence to rule out potential confounds or other factors that could impact this outcome of having a diagnosis of autism, then we simply can't, in good practice, implement a guideline. In the statement issued by the Food and Drug Administration on the changes, it also notes a missing causal relationship
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