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One such option is Mounjaro (tirzepatide), a once-weekly injectable medication that was originally approved for type 2 diabetes and is now FDA-approved for weight management in adults with obesity or overweight and at least one weight-related health condition

In subjects with baseline glucose disposal rates below 7.9 mg/kg per minute, acetyl-L-carnitine treatment significantly increased insulin sensitivity and improved glucose tolerance, with some individuals transitioning from impaired glucose tolerance to normal glucose metabolism

It was suggested that the reduction of the C-reactive protein and TNF- levels is due to the effect of L-carnitine on reducing the level of IL-6, but the mechanism of how L-carnitine reduces IL-6 is still unknown

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