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Proc Natl Acad Sci USA 97: 51015106 Tu BP, Weissman JS (2002) The FAD and O(2)dependent reaction cycle of Ero1mediated oxidative protein folding in the endoplasmic reticulum

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GSH is synthesized in two steps: First, gamma-glutamylcysteine (-GC) is formed from glutamate and cysteine, which is the rate-limiting step in GSH production