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Both classes are highly effective in reducing cardiovascular events in patients with type 2 diabetes across the spectrum of CVD risk (notably, our prior work comparing across mediation classes suggests that SGLT2is may be even more favorable than GLP-1RAs for some outcomes, and are comparable on others), and we assume that taking both together is likely to be even more beneficial
Exposure to strong acids or bases can break the peptide bonds, rendering the molecule ineffective
Retrieved 12 July 2023
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