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The biology of the IGF-1 pathway itself is well established in endocrinology and sports medicine research
Diabetes 68, 2133
That said, while the ratio is right, he notes the leucine is somewhat underdosed at 2,000 milligrams, explaining that, Research is clear that a minimum of 2,500 milligrams is needed for muscle protein synthesis. Because of those factors, Iafelice rates the product at 3 out of 5 for formulation
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