kratom and semaglutide Could medications best known for treating diabetes also help fight addiction? New research from @washumedicine suggests GLP-1 medications may help prevent treat substance use disorders across every major addictive substance studied You asked: What is kratom?

These are used in cycles or pulsed protocols to reduce resistance and minimize side effects

A direct head-to-head trial is underway (with initial results due later in 2026), and current data shows that when the highest dose of each drug is taken over a 72-week period, those on tirzepatide returned a higher percentage of total body weight loss (20.2% - 21.1% as opposed to 13.7% - 14.1% for semaglutide (as detailed in the New England Journal of Medicine Study of May 2025)

While both compounds interact with GLP-1 and GIP pathways, Retatrutide differs as a triple agonist involving glucagon receptor activity

In addition, GCGR activation in the adipose tissue, and possibly brown fat, increases thermogenesis and resting energy expenditure [50,51]