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Talei names superficial skin texture (i.e., fine lines, wrinkles) and pigmentation (i.e., sun damage, melasma) as factors that can exacerbate under-eye shadows and darkening

Unlike Rybelsus, which is a peptide formulation requiring strict dietary restrictions, orforglipron is a small-molecule, non-peptide GLP-1 agonist

Also, they stimulate the endothelium to produce nitric oxide, reduce oxidative stress, and have antiatherogenic and antiinflammatory effects

Since ED is a common comorbidity in this group and patients often avoid reporting it actively due to a sense of shame, all male patients with genital involvement, high disease activity, or subjective reports of decreased QoL should be included in the systematic assessment