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Seek medical advice if you experience: Persistent palpitations a sensation of your heart racing, pounding, or fluttering that lasts for extended periods or occurs frequently Resting heart rate consistently above 100 beats per minute particularly if this represents a significant change from your baseline Chest pain or discomfort any chest tightness, pressure, or pain, especially if accompanied by shortness of breath Dizziness or lightheadedness particularly if severe or associated with near-fainting episodes Shortness of breath difficulty breathing at rest or with minimal exertion that is new or worsening Unusual fatigue or weakness extreme tiredness that interferes with daily activities Seek emergency medical attention (call 999) if you experience: Severe chest pain or pressure Difficulty breathing or severe shortness of breath Fainting or loss of consciousness Chest pain radiating to the arm, jaw, or back Rapid heart rate accompanied by confusion or altered mental state Patients with pre-existing heart conditions, including arrhythmias, heart failure, or coronary artery disease , should have closer monitoring and may benefit from more frequent follow-up appointments

Patients on chemotherapy (cisplatin, cyclophosphamide may interact)

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The role of tumor-associated macrophages in osteosarcoma progression - therapeutic implications