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have demonstrated that homozygous carriers of SLC47A1 rs2289669 A-allele show a larger reduction in HbA1c to metformin therapy compared to the prevalent G-allele (Becker et al., 2009a)
278 More importantly, p53 can adjust gluconeogenesis, glycolysis, and glucose uptake to affect glucose metabolism in peripheral tissues
Propolis extract and its bioactive compoundsfrom traditional to modern extraction technologies
Therefore, targeting glucose metabolism holds promise not only for directly suppressing tumor growth but also for enhancing the efficacy of other therapeutic modalities through metabolic synergy or mechanistic complementation [122]
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