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Furthermore, in signaling studies that used cell lines with recombinantly expressed human GIPR or GLP-1R, tirzepatide stimulated cyclic adenosine monophosphate (cAMP) accumulation by either receptor with potency similar to that of native GIP and approximately 13-fold weaker than that of native GLP-1 [1]
Use of semaglutide for weight loss outside of FDA-approved indications is considered off-label
It may help to remember that the needles used for GLP-1 medications are very thin and short, designed specifically for subcutaneous (under the skin) use rather than deep muscle injections
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