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It was originally isolated from the blood of rabbits that had been induced into slow-wave (delta) sleep, which is how it got its name
Therefore, it can be inferred that the extent of HSF1 release is closely related to the intracellular burden of misfolded proteins
It is also well known that physical activity can increase the diversity of intestinal microbiota, enhance SCFA production and stimulate anti-inflammatory mechanisms, mainly aerobic exercises, such as running, cycling, fitness exercises [86, 156, 157]
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