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As the committee passed the drugs, Shabbir Imber Safdar was quoted in NBC News, saying, Compounding shouldnt be used as an end run around the safety assurances of the FDA approval process. Time Magazine also cited our concerns about the standards at 503A compounding pharmacies and the potential for people to think that these peptides have robust clinical evidence behind them as a result of being added to the list

These studies were supported by P50 GM115318 from the National Institute of General Medical Sciences (R.M.K., M.W.M., K.R.), U54 DK120342 from the National Institute of Diabetes and Digestive and Kidney Disease/Office of Research on Womens Health (K.R.), U54 HL170326 from the National Heart Lung and Blood Institute/Office of Research on Womens Health, R21 AR077782 (K.R

Efflux transporters like P-glycoprotein (P-gp) actively transport substrates out of enterocytes back into the intestinal lumen, limiting systemic drug exposure