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Studies have found that high NNMT expression promotes the release of inflammatory factors in adipose tissue, and NNMTi can effectively alleviate adipose inflammation and improve the microenvironment by inhibiting NNMT
Routine B12 monitoring is not mandated for tirzepatide, but baseline and periodic testing should be considered for high-risk patients, including those over 65, on concurrent metformin, with gastrointestinal disorders, or experiencing symptoms such as fatigue, neuropathy, or cognitive changes
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