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2, Supplementary Fig
Choose the same day each week for consistency (many prefer Sunday evenings) Allow refrigerated medication to reach room temperature before injecting Clean the injection site with alcohol and let it dry completely Pinch a fold of skin and insert the needle at a 45-90 degree angle Inject slowly over 5-10 seconds Hold the needle in place for 10 seconds after completing the injection Rotate sites in a systematic pattern (left abdomen, right abdomen, left thigh, right thigh) Injection timing preferences vary among users
call 999 or go to your nearest emergency department for severe symptoms such as persistent vomiting, severe abdominal pain, or signs of dehydration Report any suspected side effects to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk, and to your trial team as instructed in your participant information sheet How Retatrutide Works in the Body Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors, creating a synergistic effect on appetite suppression, caloric intake reduction, and energy expenditure that distinguishes it from currently approved therapies
In the FDA labeling for Wegovy tablets, adults taking Wegovy tablets achieved an average ~13.6% body-weight loss at 64 weeks, compared with ~2.4% with placebo, alongside lifestyle changes
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