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We recently demonstrated that G6PD deficiency could be induced by either pharmacological inhibitors or G6PD siRNA, which impairs redox homeostasis and causes increased ROS levels and reduced GSH levels in monocytes and endothelial cells

The proposed mechanism is that in the absence of efficient GST-mediated conjugation, SFN is cleared more slowly, allowing it to circulate in its active form for a longer duration and potentially exert stronger biological effects (57)

Diagnosis and treatment of infertility in men: AUA/ASRM guideline PART II