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Minocycline Minocycline, a tetracycline antibiotic, can penetrate the BBB, inhibit the M1-type (pro-inflammatory) polarization of microglia, and attenuate the microglial expression and release of pro-inflammatory factors such as IL-1, IL-18, and TNF- [152,153,154]
Cardiovascular and Metabolic Safety Because PT-141 may cause transient elevations in blood pressure, it is contraindicated in patients with uncontrolled hypertension or significant cardiovascular disease
Although it is not typically flagged in routine drug tests, it can show up in specialized tests that focus on growth factors or PEDs
10.1186/s41231-019-0050-7 135 SixN.SeptierD.Chaussain-MillerC.BlacherR.DenBestenP.GoldbergM
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