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encoding two cytosolic, two peroxisomal, three chloroplastic, and one mitochondrial isoforms (Texeira et al., 2004, 2006)

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94 In the colonic mucosa of UC patients, one or more of the three ER stress pathways are activated, resulting in unbalanced protein synthesis and abnormal protein folding, which in turn exacerbates the inflammatory response and intestinal barrier disruption of UC