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DOI: 10.1016/j.molmet.2020.101102

Individuals with type 2 diabetes taking Wegovy alongside insulin or insulin secretagogues (such as sulphonylureas) face increased hypoglycaemia risk

Weeks 14: 2.5 mg weekly (starter dose) Weeks 58: 5 mg weekly Weeks 912: 7.5 mg weekly Weeks 1316: 10 mg weekly Weeks 1720: 12.5 mg weekly Maintenance: up to 15 mg weekly Some people stay at lower doses for longer if they feel comfortable and still see results

315 The expression levels of GLP-1R, PKA/CREB signaling pathway components, and inflammation-related proteins (such as TNF-, IL-1, and IL-6) in the rat knee cartilage tissue were measured using Western blot and immunoprecipitation techniques