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In both studies, tesamorelin-treated patients completing the 26-week treatment period were re-randomized to blinded therapy with either daily placebo or 2 mg tesamorelin for an additional 26-week treatment period (Extension Phase) in order to assess maintenance of VAT reduction and to gather long-term safety data

Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling