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nature.com 9NIH / NCBI StatPearls (2024)

These cardiovascular benefits may relate to the peptide's stress-reducing effects, since chronic stress contributes to hypertension and cardiac dysfunction

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When the rapid onset or threshold concentration of a concomitant orally administered medication is a critical determinant of effectiveness (such as with analgesics, antibiotics, and oral contraceptives), the medication should be administered at least 1 hour prior to SYMLIN injection or 2 hours after SYMLIN injection [see WARNINGS AND PRECAUTIONS and CLINICAL PHARMACOLOGY ]