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Moving to human evidence, the review analyzed two small clinical trials
Mientras que GIP acta casi exclusivamente a nivel pancretico, existen receptores para GLP-1(R-GLP1) ampliamente distribuidos en el pncreas endocrino (alfa y ), en rganos perifricos (corazn, estmago, nervio vago) y en varias regiones del SNC, incluyendo el hipotlamo y el tronco cerebral
32 Shor et al used a nationwide Canadian EHR database to compare 46,334 patients taking GLP-1 RAs with 92,668 controls over a follow-up period of 6 months to 3 years
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