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For example, potential effects on alcohol dependency are supported by a recent real-world population propensity-score-matched study of 83,825 patients with obesity, which showed that semaglutide, compared with other non-GLP-1-based obesity medications, was associated with a 50% lower risk for incident and recurrent alcohol use disorders over a 12-month period regardless of T2D status 24

Several mechanisms including glucotoxicity, lipotoxicity, altered secretion of adipokines/cytokines, hepatokines (mainly higher circulating fetuin-A levels), stimulation of multiple inflammatory pathways, reduced bile-acid synthesis, endoplasmic reticulum stress, increased oxidative stress, mitochondrial dysfunction and alterations in gut microbiota/gut-derived endotoxins, in a complex interplay with genetic predisposition, drive the evolution of inflammation, hepatocellular injury and fibrosis [2426]

Coverage requirements depend on why your healthcare provider has prescribed Wegovy, but common criteria include a higher body mass index (BMI), a reduced-calorie diet, and increased physical activity

But the evidence supporting their effectiveness compared to injectable formulations remains limited