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This connection is illustrated by bedaquiline, a clinically approved ATP synthase inhibitor, which disrupts energy production linked to CCM and exhibits potent bactericidal activity (Lakshmanan and Xavier, 2013)
SURPASS-5 (PMID 35133415) tested tirzepatide as add-on to titrated insulin glargine, demonstrating glycemic improvements without disproportionate hypoglycemia
The rodent data is real, but the pivotal 534-subject obesity trial did not beat placebo and development stopped in 2007
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