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SAM acts primarily as a universal methyl donor in the synthesis of methylated compounds such as neurotransmitters (adrenaline, noradrenaline), DNA, RNA, phosphatidylcholine and creatine ( Reference Brosnan, da Silva and Brosnan 14 )
Advanced Handling Storage optimisation: Use desiccants, log temperatures, avoid fluctuations
Lifestyle: Lack of physical activity can also contribute to increased acidity
Therefore, we conducted this study in accordance with the "Ethical Guidelines for Medical Research Involving Human Subjects (enacted by the Ministry of Health, Labor, and Welfare in Japan), section 121 (2) (a) (c). This was a de-identified study using archived tissue obtained from judicial autopsy cases, and information on the implementation of the study was posted on our website ( If they were requested to refuse the use of the samples for research, they were excluded from the study
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