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Immediately following injections, pramlintides plasma concentration spikes into pharmacological levels, which explains why nausea is the dose limiting adverse event, given that amylin receptors are in the vomit center of the brain
More in-depth research that clarifies the roles of these components of the GST-detoxification system are much needed, in order to produce compounds that have minimal side effects and high GST selectivity
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Furthermore, in vivo experiments using MPTP-treated mice revealed that AST reversed behavioral deficits, preserved tyrosine hydroxylase (TH) expression, and reduced neuronal apoptosis, even in the presence of miR-7 knockdown
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