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Combining treatment with calcium, vitamin D, and weight-bearing exercise is essential rather than optional for this demographic
S1P is stored in platelets and released upon platelet activation
Feb 2 2021;113(2):370-379
Weight Loss Results: In a 48-week trial with people who had obesity: 12 mg dose: Average weight loss of 24.2% 8 mg dose: Average weight loss of 17.5% Placebo: Weight loss of 2.1% Let me put that in perspective: If you weigh 250 pounds: 24.2% weight loss = 60 pounds lost And people were still losing weight when the trial ended (no plateau reached yet) How this compares to other medications: Semaglutide (Wegovy): ~15% weight loss Tirzepatide (Zepbound): ~20% weight loss Retatrutide: ~24% weight loss This is the most significant weight loss we've seen with any medication to date
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