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This is also in line with a study in older 16 months old APOE-TR mice which found the same pattern of decreased LCAs and increased SCAs in E4s compared to E3s, particularly in males (Shang et al., 2020)
According to current guidelines, they should be avoided if you are pregnant, hypersensitive to GLP-1, or living with severe gastrointestinal conditions such as inflammatory bowel disease (IBD)
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