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Sphingosine-1-phosphate signal transducer and activator of transcription 3 signaling pathway contributes to baicalein-mediated inhibition of dextran sulfate sodium-induced experimental colitis in mice

However, two arguments support a different GSH binding mode in MGST1: 1) in electron crystallography maps of MPGES1 the horseshoe shape of GSH could be observed at a similar resolution 26 , and 2) MGST1 has the unique ability to use N-acetyl-L-cysteine as substrate supporting a different GSH site (discussed further below)