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2396-C WESTERN DIET DAMPENS T REGULATORY CELL FUNCTION TO FUEL HEPATIC INFLAMMATION IN METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE Sudrishti Chaudhary 1 , Ravi Rai 1 , Pabitra Pal 1 , Dana Tedesco 2 , Aatur Singhi 3 , Satdarshan (Paul) Monga 1 , Arash Grakoui 2 , Smita Iyer 1 and Reben Raeman 1 , (1)University of Pittsburgh, (2)Emory University School of Medicine, (3)University of Pittsburgh Medical Center Background: The immunosuppressive T regulatory cells (Tregs) regulate immune responses and maintain immune homeostasis, yet their functions in metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis remains controversial

Code availability All analyses were performed using publicly available software packages cited in the Methods

Commonly reported issues include mild gastrointestinal discomfort, particularly when starting the compound, and temporary headaches during the adjustment period

Most of these are isolated cases linked to unsupervised use