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Semaglutide and similar GLP-1 receptor agonists have become widely prescribed for weight management, with clinical trials showing average weight reductions of 15-22% in patients
Dulaglutide (Trulicity): A long-acting GLP-1 RA consisting of two GLP-1 analog sequences covalently linked to an Fc fragment, which extends its half-life to ~5 days
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However, they operate through distinct receptors and second messenger systems
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