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In parallel, the SURMOUNT trials, which focused on individuals with obesity with or without diabetes, revealed substantial and sustained weight loss that exceeded outcomes typically achieved with existing pharmacologic options
Interestingly, BSO significantly enhanced L-PAM-induced apoptosis in TP53 -mutated MM cell lines, suggesting that BSO+L-PAM can achieve p53-independent cell death as described previously
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Many patients stay on semaglutide long term under medical supervision, since stopping the medication may allow hunger and weight to return
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