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Shen W, et al
Unlike human studies, where sampling tissues and biofluids are primarily limited to blood plasma, muscle, adipose, urine & fecal samples, mouse models allow researchers to sample multiple organs and tissues, often impossible due to ethical limitations in human volunteers
Although substantial variation between elephant B and C occurred regarding the magnitude of recall responses to rEE2 or rMCP antigens in post-vaccination samples, elevated IFNG expression or levels that exceeded baseline values after rMVA or protein boost vaccinations were observed in blood from both elephants after stimulation with rMCP (Fig
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