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Older people and people with digestive tract conditions are most at-risk for developing vitamin B12 deficiencies

Vitamin B12 and Aging Being deficient in Vitamin B12 can speed up aging by limiting B12 availability to mitochondria, tiny organelles found in all cells that make ATP, the energy molecule

Factors like unmeasured variables causing bias, differences in dosing, using the brand name as a proxy to target dose and missing data could also have affected results

The FDA cannot reliably determine how often this side effect occurs or if the drug actually caused the ileus due to the voluntary nature of the reports