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The most commonly reported side effects in clinical trials are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, which are typically most pronounced during the dose titration phase and tend to improve over time
It is also noteworthy that central GLP-1R signaling appears to be impaired in chronic stress conditions or under the influence of a high concentration of glucocorticoids, often observed in patients with depression
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