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Efficacy and safety of tirzepatide monotherapy compared with dulaglutide in Japanese patients with type 2 diabetes (SURPASS J-mono): a double-blind, multicentre, randomised, phase 3 trial
So does the activity of matrix metalloproteinases like MMP-2, the enzymes whose job is to chew matrices back down
Melanotan 1 keeps all thirteen residues and changes two of them, Nle for Met and D-Phe for L-Phe, which is why the 1980 characterisation described it as an alpha-melanotropin with unusually prolonged activity
That said, I switched to working remotely and started taking a GLP-1 around the same time in 2022
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