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Some claudins act in part by controlling barrier function and paracellular permeability (e.g., claudin-2, -7 and -12), while others control barrier properties such as electrical tightness of the junctions (claudin-1, -3, -4, -5 and -8) (Ding et al., 2012

With a plasma half-life estimated at 30 to 45 minutes after intravenous administration, DSIP begins degrading immediately

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