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All injectable GLP-1 medications follow a gradual dose-escalation approach to minimize gastrointestinal side effects, which are the most common adverse reactions

However, the relative contributions of GIP and GLP-1 to the incretin effect and glycemic control under physiological and pharmacological conditions remain a topic of debate

Biochemical assays have shown strong activation of GIPR with measurable activation of GLP 1R and GCGR, producing a coordinated receptor engagement profile that differs from single receptor agonists such as GLP 1 selective peptides or dual agonists such as GLP 1 and GIP analogs

Both are used for diabetes management