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Paul Gross, a physician specializing in diabetes, weight management and metabolic dysfunction
Diarrhea was reported across all dose groups but was significantly more frequent and more severe at higher doses
The compound failed its Phase IIb obesity endpoint in 2007, and Metabolic Pharmaceuticals terminated clinical development the same year
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Retatrutide's Half-Life Is Approximately 6 Days In the Phase 1b multiple-ascending-dose trial, the pharmacokinetics of LY3437943 were dose proportional and its half-life was approximately 6 days (Urva et al., Lancet, 2022)
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