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Variants of OXM resistant to DPP-IV (achieved by addition of PEG [86], fatty acids [87], substitution of certain amino acids [85] or even combined modifications [88]) have been advanced to circumvent the limited clinical potential of the native peptide

doi: 10.18388/abp.2020_5345 92 GongTDuJLiSWHuangHQiXL

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However, GLP-1 prices are expected to decrease over time, as these things do, as Sir Stephen ORahilly outlined during his presentation at the 2022 Royal Society conference on causes of obesity