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Enhancing vulnerability of Afatinib using Erastin via xCT-mediated ROS/P38MAPK signaling feedback loop in gastric cancer cells
174 Similarly, endogenous microRNAs (e.g., miR-451 and miR-326) have been shown to negatively regulate MDR1 expression and restore drug sensitivity in breast and gastric cancers
And it does not eliminate the need for the one thing that protects patients more than any regulatory change: a physician who understands their biology, orders the appropriate labs, determines clinical indication, and monitors their response
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