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GLP-1R plays a role in the central nervous system (CNS) regulation of appetite
Researchers injected ipamorelin (100ug/kg) three times per day for 3 months in female rats
10.1016/s0006-3495(93)81254-2 345
Nevertheless, the target for GIPR antagonists is believed to be a neuronal population in the brain, as a peptideantibody conjugate that blocks GIPR while activating GLP-1R required central GIPR for maximal weight loss in DIO mice, as determined using mice lacking Gipr in cells expressing synapsin 12
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