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If the peptide were made in the body, Szabo and his colleagues wrote, one would expect that over the course of decades, researchers would have identified the gene that encodes it, the cells that make it, the receptors that it interacts with, and the levels at which it occurs in the body

Human brain samples Neuropathological examination of postmortem brain samples from normal subjects and AD patients was performed via procedures previously established by the Boston University Alzheimers Disease Center (BUADC)

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10) indicate a complex interaction between NFT derivatives and the Nrf2 pathway