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Pathological causes of elevated B12 warrant careful consideration: Haematological disorders : Myeloproliferative neoplasms (polycythaemia vera, chronic myeloid leukaemia), acute leukaemia, and lymphoproliferative disorders can increase B12-binding proteins (transcobalamin and haptocorrin), elevating total serum B12 [3] Liver disease : Hepatocellular damage releases stored B12 into circulation
Deficiency of vitamin B12 may cause tiredness, weakness, constipation, loss of appetite, weight loss and megaloblastic anemia (a condition when red blood cells become larger in size than normal)
Pickart's group showed it attracted immune cells and endothelial cells to wound sites, stimulated nerve outgrowth, and increased the production of vascular endothelial growth factor (VEGF), which promotes new blood vessel formation
This analgesic and anti-inflammatory action is due to the antagonism of bradykinin and due to inhibition of prostaglandin biosynthesis
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